Natalia Artymuk
Russia
Title: The effect of dietotherapy on the dynamics of anthropometric and basic metabolic indicators in infertile women with obesity
Biography:
Professor Natalia Artymuk - Head of the Department of Obstetrics and Gynecology of Kemerovo State Medical University, President of the Kemerovo Regional Public Organization "Association of Obstetricians-Gynecologists", Chief Specialist of the Ministry of Health of the Russian Federation of Obstetrics and Gynecology in the Siberian Federal District, member of the Presidium of the Board of the Russian Society of Obstetricians-Gynecologists.
Abstract:
Statement of the Problem: Obesity is currently a growing problem worldwide and is associated with serious health risks. This is a global epidemic, and its consequences for morbidity and mortality, both in adults and in children, are becoming increasingly important. The first basic measure for correcting body weight as part of pre-conception care is to prescribe a balanced hypocaloric diet in combination with exercise and correction of eating behavior using behavioral therapy.
Purpose of this study was to evaluate the dynamics of anthropometric, hormonal and metabolic parameters in infertile obese women with a balanced hypocaloric diet.
Methodology & Theoretical Orientation: The study included 23 infertile women of reproductive age with grade I gluteofemoral obesity. All patients were prescribed a balanced, low-calorie diet (1200 kcal / day), exercise, and behavioral therapy. An anthropometric, metabolic and hormonal parameters were conducted before and after 12 months after treatment.
The results. Twenty (87%) of the 23 women included in the study completed the treatment protocol. A decrease in body weight from 4 to 24 kg was registered in all patients who completed the protocol by an average of 10.58 ± 5.70 kg (p <0.001). A statistically significant decrease in the volume of adipose tissue was recorded both due to subcutaneous and visceral fat and other indices p <0.001). The decrease of body weight was accompanied by a statistically significant decrease in the level of leptin (p <0.001), E1 (p = 0.049), E2 (p = 0.032), fasting glycemia (p <0.001), HOMA-R (p = 0.002), cholesterol (p < 0.001), TG (p = 0.004), cholesterol-LDL (p = 0.001), Ka (p <0.001) and an increase in the content of progesterone (p = 0.030). The ovulatory menstrual cycle was restored in all women (p = 0.007), the desired pregnancy within a year occurred in 1 patient.
Conclusion & Significance: The use of a hypocaloric diet for 12 months in infertile women with obesity of the first degree helps to normalize metabolic processes, reduce body weight and in 100% of cases restore the ovulatory menstrual cycle.