Speaker Biography

Mina Garashova


Title: Obesity and Endometrial Pathology in Postmenopausal Women In Azerbaijan

Mina Garashova

Dr Garashova is an experienced healthcare provider in the field of obstetrics&gynecology and a sciensist.. She had years of experience in research, evaluation, teaching and administration both in hospital and education institutions. Her first scientific research was devoted to the study of clinical significance of soluble FAS antigen and VEGF-factor in women with ovarian cancer. Her present research is devoted to the study of incidence, pathogenetic mechanisms and clinical manifestations of tumors of the genitalia in postmenopausal women. She has more than 40  articles and Textbook of Gynecology for student of a medical university. Dr.Garashova also has experience in private healthcare sector management.



Statement of the Problem: It is known that obesity is a predisposing factor for many pathological conditions, including the hyperplastic processes of the endometrium and endometrial cancer, thereby reducing the quality of life. Researchers established a relationship between an increase in body mass index (BMI), the age of a woman, and the presence of endometrial cancer. Obesity plays a significant role in the development of endometrial cancer type I and is characterized by an increase in its frequency by 4-5 times compared with women with normal body weight. An increase in BMI for every 5 kg / m2 increases the likelihood of endometrial cancer by 1.5 times. Metabolic and endocrine changes in postmenopausal women associated with obesity may explain the increased incidence of endometrial pathology. The purpose of this study is to reveal the relationship between the increased BMI and the incidence of endometrial pathology in postmenopausal women in Azerbaijan. Materials&Methodology: 115 postmenopausal women with a thickening of the endometrium (according TVU data) were examined.  Of these, 50 (43.5%) had endometrial cancer, 34 (29.6%) had complex endometrial hyperplasia without atypia, 15 (13%) had atypical endometrial hyperplasia, and 16 (13.9%) patients had endometrial polyp.  The average age of patients was 59.7 ± 0.6 (50-83) years.  The body mass index was calculated for all patients and was average 32.3 ± 6.7 (23.2-58) kg / m2. Results: Among 50 patients with endometrial cancer 22 (44%) had I degree of obesity, 12 (24%) had II degree, and 7 (14%) patients had III degree of obesity (BMI>40 kg/m2). 20 (58.8%) of patients with complex endometrial hyperplasia without atypia, and 10 (66.7%) with atypical hyperplasia had different degrees of obesity with BMI>30kg/m2. 11(68.7%) patients of 16 with endometrial polyp were obese. Thus, 82 (71.3%) of 115 postmenopausal women with increased endometrial thickness were obese.  Conclusion: Increased BMI is a consistent and leading risk factor for endometrial hyperplasia and endometrial cancer in postmenopausal women.  Recommendations: to increase the awareness of women about the screening methods, to improve the lifestyle and nutritional habits for the prevention of gynecological and other obesity related diseases.